Biomaterial Database

Hemoglobin M Oldenburg identified as HB alpha 2 87(F8)His replaced by Tyr beta 2. 1977

G Steffens, and G Steffens, and G Buse

The abnormal hemoblobin designated as Hb M Oldenburg and already characterized as alpha 2 (72,87 or 89)His replaced by Tyr beta 2 was further identified by isolation, amino acid analysis and automated sequencing of the altered tryptic peptide alpha TIX. In this peptide the histidine in the position 87 is replaced by a tyrosine reside. Thus Hb M Oldenburg has to be described as alpha 2 87(F8)His replaced by Tyr beta 2 and is, therefore, identical with the mutant hemoblobins M Iwate and M Kankakee.

UI	MeSH Term	Description	Entries
D005860	Germany, West	The former Federal Republic of Germany which was reunified with the former German Democratic Republic in 1990.	Federal Republic of Germany,Germany, Federal Republic of
D006449	Hemoglobin M	A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha or beta chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis.
D006455	Hemoglobins, Abnormal	Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.	Abnormal Hemoglobins
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000595	Amino Acid Sequence	The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.	Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000596	Amino Acids	Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.	Amino Acid,Acid, Amino,Acids, Amino