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Lumbar cerebrospinal fluid (CSF) norepinephrine (NE) concentrations were preoperatively determined in five patients using a radioenzymatic assay technique. Stereotaxic thalamotomy was performed using depth coagulating electrodes with stimulating points at 5.0-mm intervals along the shaft. No significant alterations in prestimulation lumbar CSF NE levels were noted 12 days after electrode installation. Stimulating points within the caudate nucleus were anatomically localized using ventricular landmarks and stimulation-induced neurophysiological responses were recorded. Twelve hours after intermittent electrical stimulation of the caudate nucleus, lumbar CSF NE concentrations were significantly decreased. Our data suggest the presence of noradrenergic pathways in man that are inhibited by caudate nucleus stimulation.
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
May 1974,
Research communications in chemical pathology and pharmacology,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
January 1975,
Zhonghua yi xue za zhi,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
March 1975,
Brain research,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
December 1977,
The Indian journal of medical research,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
January 2011,
The open neuroimaging journal,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
January 1962,
Acta physiologica Polonica,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
January 1981,
Neuroscience and behavioral physiology,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
April 1983,
Brain research bulletin,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
April 1979,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
J H Wood, and
C R Lake, and
M G Ziegler, and
J Van Buren
August 1980,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
