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The results of superselective intra-arterial chemotherapy with Mitomycin C (SIAC) in cases of hepatic neoplasms continue to be poor. Survival time was related to the percentage of hepatic replacement (PHR) but only 19% of the patients with Stage I tumours (PHR < 25%) survived for over 5 years and all the others died within 4 years. The patients with hepatic metastases from colorectal cancer achieved a significantly better cumulative 5-year survival figure than those with hepatocellular cancer (P < 0.05). The median survival times for patients with hepatic metastases from colorectal cancer, hepatocellular cancer and gallbladder cancer were 15 months, 6 months and 13 months, respectively. The overall response rate was only 27% (26/97), that for primary liver cancer 20% (7/35), that for hepatic metastases from colorectal cancer 22% (8/37) and that for gallbladder cancer 44% (11/25) and the patients who responded to SIAC (n = 27) had a significantly better cumulative 5-year survival rate (P < 0.005). Cessation of SIAC was necessary in 74% (72/97) of the cases, because of tumour progression in 53% (51/97), major complications in 19% (18/97) and patient refusal in 3% (3/97). The results of this trial may be regarded as disappointing, and we are going to use SIAC for Stage I tumours only. Resection of the tumour continues to provide the only chance of a permanent cure with these patients.
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
January 1993,
Surgical oncology,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
February 1988,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
July 1993,
The British journal of surgery,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
December 1993,
The British journal of surgery,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
January 1980,
Acta radiologica. Oncology,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
October 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
March 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
May 1993,
Der Radiologe,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
February 2014,
Journal francais d'ophtalmologie,
J Mäkelä, and
T Tikkakoski, and
A Leinonen, and
T Siniluoto, and
A Karttunen, and
M I Kairaluoma
August 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
