BIOMAT Database Logo BIOMAT Database Logo

UCE6, a new antitumor antibiotic with topoisomerase I mediated DNA cleavage activity, from actinomycetes. 1993

N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano

UI MeSH Term Description Entries
D011809 Quinones Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D004249 DNA Damage Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. DNA Injury,DNA Lesion,DNA Lesions,Genotoxic Stress,Stress, Genotoxic,Injury, DNA,DNA Injuries
D004264 DNA Topoisomerases, Type I DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. DNA Nicking-Closing Protein,DNA Relaxing Enzyme,DNA Relaxing Protein,DNA Topoisomerase,DNA Topoisomerase I,DNA Topoisomerase III,DNA Topoisomerase III alpha,DNA Topoisomerase III beta,DNA Untwisting Enzyme,DNA Untwisting Protein,TOP3 Topoisomerase,TOP3alpha,TOPO IIIalpha,Topo III,Topoisomerase III,Topoisomerase III beta,Topoisomerase IIIalpha,Topoisomerase IIIbeta,DNA Nicking-Closing Proteins,DNA Relaxing Enzymes,DNA Type 1 Topoisomerase,DNA Untwisting Enzymes,DNA Untwisting Proteins,Topoisomerase I,Type I DNA Topoisomerase,III beta, Topoisomerase,III, DNA Topoisomerase,III, Topo,III, Topoisomerase,IIIalpha, TOPO,IIIalpha, Topoisomerase,IIIbeta, Topoisomerase,Topoisomerase III, DNA,Topoisomerase, TOP3,beta, Topoisomerase III
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000192 Actinomycetales An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments. Corynebacteriaceae,Coryneform Group
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000903 Antibiotics, Antineoplastic Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic

Related Publications

N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity, from Streptomyces sp.
July 1992, The Journal of antibiotics,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
UCT4B, a new antitumor antibiotic with topoisomerase II mediated DNA cleavage activity. Structure determination.
February 1993, The Journal of antibiotics,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces.
October 1990, The Journal of antibiotics,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
UCT1072s, new antitumor antibiotics with topoisomerase II mediated DNA cleavage activity, from Aspergillus sp.
November 1999, The Journal of antibiotics,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
Antitumor quinolones with mammalian topoisomerase II mediated DNA cleavage activity.
May 1992, Cancer research,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
Bacterial cell killing mediated by topoisomerase I DNA cleavage activity.
November 2005, The Journal of biological chemistry,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110.
February 1993, Cancer research,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.
August 1989, Cancer research,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
Compounds with antibacterial activity that enhance DNA cleavage by bacterial DNA topoisomerase I.
April 2007, The Journal of antimicrobial chemotherapy,
N Fujii, and Y Yamashita, and S Chiba, and Y Uosaki, and Y Saitoh, and Y Tuji, and H Nakano
Minimal DNA duplex requirements for topoisomerase I-mediated cleavage in vitro.
July 1990, The Journal of biological chemistry,
Copied contents to your clipboard!