-transparent.png){kind=logo}
The function of voltage-gated sodium channels that are responsible for action potential generation in mammalian brain neurons is modulated by phosphorylation by adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase (cA-PK) and by protein kinase C (PKC). Reduction of peak sodium currents by cA-PK in intact cells required concurrent activation of PKC and was prevented by blocking phosphorylation of serine 1506, a site in the inactivation gate of the channel that is phosphorylated by PKC but not by cA-PK. Replacement of serine 1506 with negatively charged amino acids mimicked the effect of phosphorylation. Conversion of the consensus sequence surrounding serine 1506 to one more favorable for cA-PK enhanced modulation of sodium currents by cA-PK. Convergent modulation of sodium channels required phosphorylation of serine 1506 by PKC accompanied by phosphorylation of additional sites by cA-PK. This regulatory mechanism may serve to integrate neuronal signals mediated through these parallel signaling pathways.
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
March 2005,
Proceedings of the National Academy of Sciences of the United States of America,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
June 1998,
Current opinion in neurobiology,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
July 1995,
Proceedings of the National Academy of Sciences of the United States of America,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
October 1998,
The Journal of biological chemistry,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
October 2014,
European journal of pharmacology,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
June 1989,
Science (New York, N.Y.),
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
June 1990,
The Journal of biological chemistry,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
November 1993,
Molecular and cellular biochemistry,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
January 1998,
The Journal of physiology,
M Li, and
J W West, and
R Numann, and
B J Murphy, and
T Scheuer, and
W A Catterall
March 1996,
Journal of neurochemistry,
