-transparent.png){kind=logo}
The immunogenicity and adverse reaction of an inactivated hepatitis A (HA) vaccine were investigated. Sixty healthy adult volunteers who lacked antibody to HA virus (anti-HAV) received three doses of vaccine containing 720 enzyme-linked immunosorbent assay (ELISA) units (EL.U) according to a 0, 1 and 6 month schedule. Blood tests for serum liver enzymes and anti-HAV were performed at screening 7 days prior to, and 1, 6 and 7 months after the first dose. Anti-HAV was tested by radio immunoassay and ELISA for titre determination. The seroconversion rates measured by ELISA were 98.3% (59/60) at months 1 and 6 and 100% at month 7. Sixty-one per cent (109/180) of the documented injections were followed by local symptoms, essentially mild soreness at the site of injection; and 22.2% (40/180) by minor general symptoms including malaise, fatigue and lethargy. It is concluded that HA vaccine is highly immunogenic and safe. It may replace immunoglobulin as an effective method of preventing HA virus infection in adults.
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
December 1990,
Vaccine,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
August 2004,
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
October 2005,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
April 1991,
The Journal of infectious diseases,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
October 1996,
Scandinavian journal of gastroenterology,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
February 2012,
Vaccine,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
July 2011,
The Pediatric infectious disease journal,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
June 2008,
The Journal of infectious diseases,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
February 2001,
Vaccine,
Y C Horng, and
M H Chang, and
C Y Lee, and
A Safary, and
F E Andre, and
D S Chen
August 2010,
Vaccine,
