BIOMAT Database Logo BIOMAT Database Logo

Pulmonary morbidity 10-18 years after irradiation for Hodgkin's disease. 1993

E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Department of Medical Oncology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam.

Pulmonary function tests were performed in 78 patients who had been curatively treated for Hodgkin's disease with mantle field irradiation 10-18 years ago. Mean values of the total lung capacity (95.2%), vital capacity (VC) (95.9%), forced expiratory volume in 1 s (FEV1) (90.6%), and carbon monoxide diffusing capacity per unit alveolar volume (82.7%) showed significant deviations from the predicted normal values, standardised for age, sex, race and height. In a multiple regression analysis the normalised total dose of irradiation, the field of irradiation, and the interval since irradiation had independent negative effects on the test results. Patients reported more coughing, wheezing and dyspnoea on exertion in comparison with hospital-visitors. Their smoking habits and reported pulmonary disease were not different. It is concluded that small, but significant impairment of pulmonary function exists after a follow-up of 14 (2) years [mean (S.D.)]. The clinical impact of these findings seems, however, minimal. Further avoidance of pulmonary toxicity requires a careful quantitative study of the effects of the radiation dose and irradiated volume.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011878 Radiotherapy The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions. Radiotherapy, Targeted,Targeted Radiotherapy,Radiation Therapy,Radiation Therapy, Targeted,Radiation Treatment,Targeted Radiation Therapy,Radiation Therapies,Radiation Therapies, Targeted,Radiation Treatments,Radiotherapies,Radiotherapies, Targeted,Targeted Radiation Therapies,Targeted Radiotherapies,Therapies, Radiation,Therapies, Targeted Radiation,Therapy, Radiation,Therapy, Targeted Radiation,Treatment, Radiation
D003371 Cough A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs. Coughs
D004417 Dyspnea Difficult or labored breathing. Orthopnea,Platypnea,Recumbent Dyspnea,Rest Dyspnea,Trepopnea,Breathlessness,Shortness of Breath,Breath Shortness,Dyspnea, Recumbent,Dyspnea, Rest,Dyspneas, Rest
D005260 Female Females
D005541 Forced Expiratory Volume Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity. Forced Vital Capacity, Timed,Timed Vital Capacity,Vital Capacity, Timed,FEVt,Capacities, Timed Vital,Capacity, Timed Vital,Expiratory Volume, Forced,Expiratory Volumes, Forced,Forced Expiratory Volumes,Timed Vital Capacities,Vital Capacities, Timed,Volume, Forced Expiratory,Volumes, Forced Expiratory
D006689 Hodgkin Disease A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen. Granuloma, Hodgkin,Granuloma, Malignant,Hodgkin Lymphoma,Lymphogranuloma, Malignant,Granuloma, Hodgkin's,Granuloma, Hodgkins,Hodgkin Lymphoma, Adult,Hodgkin's Disease,Hodgkin's Lymphoma,Hodgkins Disease,Lymphocyte Depletion Hodgkin's Lymphoma,Lymphocyte-Rich Classical Hodgkin's Lymphoma,Mixed Cellularity Hodgkin's Lymphoma,Nodular Lymphocyte-Predominant Hodgkin's Lymphoma,Nodular Sclerosing Hodgkin's Lymphoma,Adult Hodgkin Lymphoma,Disease, Hodgkin,Disease, Hodgkin's,Disease, Hodgkins,Hodgkin Granuloma,Hodgkin's Granuloma,Hodgkins Granuloma,Hodgkins Lymphoma,Lymphocyte Rich Classical Hodgkin's Lymphoma,Lymphogranulomas, Malignant,Lymphoma, Hodgkin,Lymphoma, Hodgkin's,Malignant Granuloma,Malignant Granulomas,Malignant Lymphogranuloma,Malignant Lymphogranulomas,Nodular Lymphocyte Predominant Hodgkin's Lymphoma
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Thyroid function 10-18 years after mantle field irradiation for Hodgkin's disease.
January 1992, European journal of cancer (Oxford, England : 1990),
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Death from Hodgkin's disease after 18 years' complete remission.
September 1975, Cancer,
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Immunity in Hodgkin's disease: status after 10 years remission.
August 1990, British journal of cancer,
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
[Surgical staging of Hodgkin's disease. Considerations after 10 years' experience].
April 1982, Minerva medica,
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
[Radiation-induced atrioventricular block 18 years after treatment of Hodgkin's disease].
September 1990, Presse medicale (Paris, France : 1983),
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Hyperparathyroidism after neck irradiation for Hodgkin's disease.
January 1984, Acta medica Scandinavica,
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Recurrence of Hodgkin's disease after 10 years: observation of 5 cases.
January 1992, Acta haematologica,
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Pulmonary function following mantle-field irradiation for Hodgkin's disease.
June 1974, Radiology,
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Pulmonary aspergilloma following total nodal irradiation for Hodgkin's disease.
May 1984, The British journal of radiology,
E A Hassink, and T S Souren, and L J Boersma, and P F Peerboom, and R Melkert, and N van Zandwijk, and J V Lebesque, and P F Bruning
Coronary heart disease mortality after irradiation for Hodgkin's disease.
June 1982, Cancer,
Copied contents to your clipboard!