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MK-852 is a novel fibrinogen receptor antagonist. A sensitive and specific radioimmunoassay has been developed for the determination of this drug candidate in plasma and urine. The immunogen was prepared by coupling to albumin via a dinitrophenylene bridge and the radioligand by reaction of the drug with the 125I-labelled Bolton-Hunter reagent. The method was specific and no immunoreactive material other than parent drug was detectable in plasma from dosed volunteers. The direct assay using 0.05 ml of plasma is sensitive to 0.2 ng ml-1 without matrix interference and has sufficient sensitivity, precision, accuracy, and selectivity for the analysis of clinical samples. The lower quantifiable limit in (diluted) urine is 50 ng ml-1.
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J D Gilbert
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E L Hand, and
M Hichens, and
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A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
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Journal of clinical pharmacology,
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M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
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Upsala journal of medical sciences,
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E L Hand, and
M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
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A S Yuan, and
E L Hand, and
M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
July 2001,
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A S Yuan, and
E L Hand, and
M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
October 1980,
Journal of pharmaceutical sciences,
A S Yuan, and
E L Hand, and
M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
November 1988,
Arzneimittel-Forschung,
A S Yuan, and
E L Hand, and
M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
September 1993,
The Journal of pharmacology and experimental therapeutics,
A S Yuan, and
E L Hand, and
M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
July 1977,
Polskie Archiwum Medycyny Wewnetrznej,
A S Yuan, and
E L Hand, and
M Hichens, and
T V Olah, and
A Barrish, and
C Fernandez-Metzler, and
J D Gilbert
June 1987,
Therapeutic drug monitoring,
