Biomaterial Database

Voltammetric study of salbutamol and application to its determination in a tablet dosage form and dissolution profiles for the dosage form. 1993

K A Sagar, and M R Smyth, and R Munden

School of Chemical Sciences, Dublin City University, Ireland.

The oxidative voltammetric behaviour of salbutamol at a glassy carbon electrode surface has been studied using cyclic voltammetry and differential pulse voltammetry. Oxidation of the drug was effected in a single irreversible, adsorption-controlled step in phosphate buffer. The process was found to be dependent on the ionic strength and the pH of the supporting electrolyte. The response was evaluated with respect to accumulation time, scan rate and other variables. Using differential pulse voltammetry following electrochemical pretreatment of the electrode surface, the drug yielded a well-defined voltammetric response in phosphate buffer, pH 5.0, at +0.75 V (vs SCE). This process could be used to determine salbutamol concentrations in the range 8 x 10(-7) M to 8 x 10(-5) M with a detection limit of 2 x 10(-7) M. The method was applied, without any interferences from the excipients, to the determination of the drug in a tablet dosage form and in drug dissolution studies. The absolute recovery for salbutamol was greater than 95% at the concentration levels studied, and reproducible voltammetric signals were obtained with a relative standard deviation of 2.4% for n = 7 at a concentration level of 8 x 10(-5) M.

UI	MeSH Term	Description	Entries
D010084	Oxidation-Reduction	A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).	Redox,Oxidation Reduction
D010710	Phosphates	Inorganic salts of phosphoric acid.	Inorganic Phosphate,Phosphates, Inorganic,Inorganic Phosphates,Orthophosphate,Phosphate,Phosphate, Inorganic
D002021	Buffers	A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.	Buffer
D002244	Carbon	A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.	Carbon-12,Vitreous Carbon,Carbon 12,Carbon, Vitreous
D004566	Electrodes	Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.	Anode,Anode Materials,Cathode,Cathode Materials,Anode Material,Anodes,Cathode Material,Cathodes,Electrode,Material, Anode,Material, Cathode
D000327	Adsorption	The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.	Adsorptions
D000420	Albuterol	A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.	Salbutamol,2-t-Butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol,Albuterol Sulfate,Proventil,Sultanol,Ventolin
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet