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A shock model was experimentally produced by intravenous injection of a lethal dose (3 mg/kg) of endotoxin under general anesthesia induced by pentobarbital sodium using 7 beagles. The effect of this endotoxic shock on the reticuloendothelial function was investigated. The blood endotoxin concentration peaked immediately after administration and decreased subsequently. However, the value still remained on an increased level (1,051 pg/ml) even at 360 min after endotoxin treatment. The lipid emulsion test as an index of reticuloendothelial phagocytotic activity and the arterial ketone body ratio as an index of the energy charge in the liver decreased after endotoxin treatment and failed to recover during the experiment. Fibronectin, one of opsonic proteins, tended to decrease after injection of the endotoxin and was significantly (p < 0.01) low at 180 and 360 min compared with the value before injection of the endotoxin. These results suggested the depression of the reticuloendothelial function during endotoxin-induced shock.
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
January 1969,
Sbornik vedeckych praci Lekarske fakulty Karlovy university v Hradci Kralove,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
January 1976,
Zeitschrift fur experimentelle Chirurgie,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
September 1977,
Beitrage zur Pathologie,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
January 1981,
Hepatology (Baltimore, Md.),
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
September 1986,
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
June 1976,
Metabolism: clinical and experimental,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
January 1975,
Verhandlungen der Deutschen Gesellschaft fur Pathologie,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
June 1962,
American journal of surgery,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
January 1994,
Acta physiologica et pharmacologica Bulgarica,
S Okano, and
M Tagawa, and
Y Hara, and
H Ejima, and
S Motoyoshi, and
N Urakawa, and
K Furukawa, and
M Onda, and
R Ogawa
November 1965,
Journal of the Reticuloendothelial Society,
