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Inhibition of appearance of pH-dependent virus-cell fusion by neutralizing monoclonal antibodies to transmissible gastroenteritis virus. 1993
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
Five MAbs, which showed neutralizing (NT) activity and recognized S (previously designated E2) glycoprotein of TGE virus TO-163, inhibited cell fusion by TGE virus in IB-RS-2 cells. Other S-specific MAbs with no NT activity did not inhibit the cell fusion. The results indicate that a neutralization epitope is same or very close to a fusion active site. The kinetics of membrane fusion following a reduction in pH were also investigated. The cell fusion appeared between 2 and 6 hr after the binding medium was added.
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