Biomaterial Database

Surface characterization and platelet adhesion studies of plasma-sulphonated polyethylene. 1993

T M Ko, and J C Lin, and S L Cooper

Department of Chemical Engineering, University of Wisconsin, Madison 53706.

Canine platelet adhesion on sulphur dioxide and allyl phenyl sulphone plasma-treated low density polyethylene (LDPE) was studied. Both 5 W plasma excitation energy-treated surfaces showed the highest S:C atomic ratio by ESCA analysis. Surface hydrophilicity increased drastically after plasma treatment. However, surface hydrophilicity decreased with time. This might be due to the diffusion of the hydrophilic functional groups into the bulk of the material and/or the migration of low molecular weight hydrocarbon species into the surface region. The allyl phenyl sulphone plasma-treated LDPE was less platelet-activating in terms of platelet adhesion and spreading and was independent of the different plasma excitation energy levels used. Sulphur dioxide plasma-treated LDPE showed a higher level platelet activation than the untreated LDPE. Among the sulphur dioxide plasma-treated LDPE samples, the sample prepared using the 5 W excitation energy was less platelet-activating than the samples treated by higher plasma excitation energies.

UI	MeSH Term	Description	Entries
D010973	Platelet Adhesiveness	The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.	Adhesiveness, Platelet,Adhesivenesses, Platelet,Platelet Adhesivenesses
D011095	Polyethylenes	Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.	Ethylene Polymers,Ethene Homopolymers,Homopolymers, Ethene,Polymers, Ethylene
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000498	Allyl Compounds	Alkenes with the general formula H2C	Compounds, Allyl
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001672	Biocompatible Materials	Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.	Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible
D013450	Sulfones		Sulfone
D013458	Sulfur Dioxide	A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.	Sulfurous Anhydride
D013499	Surface Properties	Characteristics or attributes of the outer boundaries of objects, including molecules.	Properties, Surface,Property, Surface,Surface Property
D015539	Platelet Activation	A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.	Activation, Platelet,Activations, Platelet,Platelet Activations