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Comparative analysis of human steroid sulfatase activity in prepubertal and postpubertal males and females. 1993

S A Cuevas-Covarrubias, and M A Juárez-Oropeza, and R Miranda-Zamora, and J C Díaz-Zagoya
Departamento de Bioquímica, Facultad de Medicina, UNAM, México, D.F., Mexico.

This study analyzes the role of pre or postpubertal stage and sex on the steroid sulfatase activity of human leukocytes. The prepubertal female group (2-7 yrs) presented a higher sulfatase activity than the prepubertal male group (2-7 yrs, 1.99 +/- 0.64 vs 0.99 +/- 0.31 pmol/mg protein, respectively) (p < 0.001), with a female/male ratio of 2.01. The postpubertal subjects (15-40 yrs) showed an activity of 0.77 +/- 0.19 (females) vs 0.56 +2- 0.11 pmol/mg protein (males) and a female/male ratio of 1.37. Enzymatic activity of prepubertal subjects paired by sex was higher than the postpubertal individuals (females p < 0.001 and males p < 0.005). These findings show differences in the steroid sulfatase activity of pre and postpubertal groups suggesting the possible influence of hormones secreted since puberty on the expression of this enzyme.

UI MeSH Term Description Entries
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008297 Male Males
D011627 Puberty A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT. Puberties
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001192 Arylsulfatases Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.1. Arylsulfatase,Arylsulfate Sulfohydrolase,Arylsulfate Sulfohydrolases,Arylsulphatase,Arylsulphatases,Pseudo Arylsulfatase A,Sulfohydrolase, Arylsulfate

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