-transparent.png){kind=logo}
Recent studies have demonstrated that astrocytes have much greater abilities to produce and respond to signalling molecules in the CNS than had been previously estimated. We now report a dramatic enhancement in the ability of a glutamate metabotropic receptor agonist, 1-aminocyclopentane-trans-(+/-)-1,3-dicarboxylic acid (trans-(+/-)-ACPD, to stimulate phosphoinositide hydrolysis in astrocytes cultured in a serum-free defined medium compared with astrocytes cultured in conventional serum-containing medium (43.2 +/- 3.6 vs. 3.2 +/- 0.48-fold of basal, respectively). This enhancement was selective to trans-(+/-)-ACPD as little or no difference in the response to carbachol or norepinephrine was seen between the two culture conditions. These results indicate a great potential for the phosphoinositide pathway in astrocyte glutamatergic signal transduction.
S Miller, and
R J Bridges, and
C W Cotman
July 1992,
Biochemical and biophysical research communications,
S Miller, and
R J Bridges, and
C W Cotman
November 1987,
Neuroscience letters,
S Miller, and
R J Bridges, and
C W Cotman
October 1991,
The European journal of neuroscience,
S Miller, and
R J Bridges, and
C W Cotman
May 1977,
Experimental cell research,
S Miller, and
R J Bridges, and
C W Cotman
January 1991,
Nephron,
S Miller, and
R J Bridges, and
C W Cotman
May 1985,
Proceedings of the National Academy of Sciences of the United States of America,
S Miller, and
R J Bridges, and
C W Cotman
January 1993,
Neuropharmacology,
S Miller, and
R J Bridges, and
C W Cotman
July 1986,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
S Miller, and
R J Bridges, and
C W Cotman
September 1989,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
S Miller, and
R J Bridges, and
C W Cotman
September 1982,
Endocrinology,
