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The inhibition of [3H]nitrobenzylthioinosine ([3H]NBI) binding to human parietal cortex membranes by adenosine transport inhibitors, adenosine receptor agonists and antagonists and dihydropyridines was investigated. While the adenosine transport inhibitors inhibited [3H]NBI binding with Ki values in the low nanomolar range and the adenosine A1 receptor agonist, cyclopentyladenosine, with a Ki in the low micromolar range, no IC50 values could be obtained for the adenosine receptor antagonists at concentrations up to 100,000 nM. Among the dihydropyridines (+)-nimodipine was the most potent with a Ki of 201 +/- 55 nM. Inhibition of adenosine transport thus may contribute to the clinical effects of nimodipine in the central nervous system.
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
December 1987,
Brain research,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
March 1982,
Neuroscience letters,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
July 1982,
Journal of neurochemistry,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
December 1983,
The Biochemical journal,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
August 1988,
Brain research,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
September 1985,
The Biochemical journal,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
December 1982,
European journal of pharmacology,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
February 1985,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
December 1983,
Journal of neurosurgery,
J Deckert, and
B Bereznai, and
A Hennemann, and
W Gsell, and
M Götz, and
J Fritze, and
P Riederer
December 1987,
Biochemical and biophysical research communications,
