Abnormal in vitro granulopoiesis in phenotypically normal parents of some children with congenital neutropenia. 1977

K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline

Bone marrow from hematologically normal parents of congenitally neutropenic children showed defective myeloid differentiation in vitro. In one family only the mother's marrow differentiated abnormally; in the second family both parents demonstrated abnormal myeloid differentiation. In vitro culture of bone marrow may be useful in establishing the mode of inheritance of some forms of familial neutropenia.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008297 Male Males
D009503 Neutropenia A decrease in the number of NEUTROPHILS found in the blood. Neutropenias
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D001853 Bone Marrow The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D001854 Bone Marrow Cells Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells. Bone Marrow Cell,Cell, Bone Marrow,Cells, Bone Marrow,Marrow Cell, Bone,Marrow Cells, Bone
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D006098 Granulocytes Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS. Granulocyte

Related Publications

K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
November 1985, American journal of hematology,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
April 1976, Blood,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
September 2002, Hiroshima journal of medical sciences,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
September 1980, [Rinsho ketsueki] The Japanese journal of clinical hematology,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
January 2006, Current topics in developmental biology,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
January 1980, Advances in experimental medicine and biology,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
November 2002, Blood,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
November 1975, Blood,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
August 2005, Haematologica,
K Rich, and P M Falk, and R Stiehm, and S Feig, and D W Golde, and M J Cline
April 1973, Laboratory investigation; a journal of technical methods and pathology,
Copied contents to your clipboard!