Biomaterial Database

Dose-related heart-rate, perceptual, and decisional changes in man following marihuana smoking. 1977

C F Schaefer, and C G Gunn, and K M Dubowski

Information processing was tested in 12 male subjects after smoking marihuana containing 0, 10, or 20 mg. of delta-9-tetrahydrocannabinol (THC) in three consecutive experimental sessions according to a Latin square protocol. Successful dose control was indicated both by the dose-related linear increase observed in heart rate and by preliminary assays of THC metabolites excreted in the urine. During tachistoscopic presentation of varying numbers of circles, statistically significant decrements in information processing occurred as a function of THC dosage. However, adding irrelevant information (triangles) to the display of circles eliminated effects of marihuana on accuracy of counting. Complex reaction times for oddity discrimination increased significantly only after the high dose. Nonetheless, both the social and high doses inappropriately inhibited the general tendency to respond to changing stimuli during oddity discrimination. Marihuana had no effect on field-dependence as measured by the Rod-and-frame test.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010919	Placebos	Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.	Sham Treatment
D011930	Reaction Time	The time from the onset of a stimulus until a response is observed.	Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D002188	Cannabis	The plant genus in the Cannabaceae plant family, Urticales order, Hamamelidae subclass. The flowering tops are called many slang terms including pot, marijuana, hashish, bhang, and ganja. The stem is an important source of hemp fiber.	Bhang,Ganja,Hashish,Hemp,Cannabis indica,Cannabis sativa,Hemp Plant,Marihuana,Marijuana,Bhangs,Cannabi,Ganjas,Hashishs,Hemp Plants,Hemps,Plant, Hemp,Plants, Hemp
D003657	Decision Making	The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.	Credit Assignment,Assignment, Credit,Assignments, Credit,Credit Assignments
D004192	Discrimination, Psychological	Differential response to different stimuli.	Discrimination, Psychology,Psychological Discrimination
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005364	Field Dependence-Independence	The ability to respond to segments of the perceptual experience rather than to the whole.	Dependence-Independence, Field,Dependence-Independences, Field,Field Dependence Independence,Field Dependence-Independences
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man