Biomaterial Database

[Effect of 1 alpha-OH-D3 on the bone metabolism after high tibial osteotomy]. 1993

I Yamashita, and M Miyatsu, and Y Kamo, and Y Atsuta, and T Onozawa

Department of Orthopedic Surgery, Asahikawa Rehabilitation Hospital, Hokkaido, Japan.

The effect of 1-hydroxycholecalciferol (1 alpha-OH-D3) on bone metabolism during osteotomized bone healing was investigated. The study based on 19 female patients with gonarthrosis who underwent the high tibial osteotomy. In 10 selected randomly from these patients 1 alpha-OH-D3 (1.0 micrograms/day) was administered before and after the surgery. After operation the changes in bone density (by MD-method) and biochemical parameters were followed. In the non-treated group the serum level of [Ca] x [P] product temporarily decreased at 3 days after surgery. Average bone density at two months after the surgery was 8.8% lower than the preoperative value. In contrast, 1 alpha-OH-D3 treated group showed significantly less decrease of serum [Ca] x [P] product at the third day than the control group and no significant decrease of bone density at two months after the operation. From these results, it was concluded that the 1 alpha-OH-D3 suppresses the decrease of serum Ca and P level and systemic osteopenia after osteotomy and may have an beneficial effect on fracture healing.

UI	MeSH Term	Description	Entries
D007719	Knee Joint	A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.	Superior Tibiofibular Joint,Joint, Knee,Joint, Superior Tibiofibular,Knee Joints,Superior Tibiofibular Joints,Tibiofibular Joint, Superior
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010027	Osteotomy	The surgical cutting of a bone. (Dorland, 28th ed)	Osteotomies
D010758	Phosphorus	A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D001842	Bone and Bones	A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.	Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006887	Hydroxycholecalciferols	Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.	Hydroxyvitamins D,Hydroxycholecalciferol
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly