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The effect of neonatal 6-hydroxydopamine (6-OHDA) treatment on learning and memory and on the levels of biogenic monoamines in some brain structures, as well as the influence of the nootropic drug adafenoxate on 6-OHDA effect was studied in shuttle box and step down trained rats. In mature rats injected with 6-OHDA postnatal, learning and retention were impaired and the noradrenaline (NA) level in the frontal cortex and hippocampus was decreased. Adafenoxate abolished the amnestic effect of 6-OHDA and restored the NA level to normal in the above-mentioned brain structures. This finding suggests the important role of the noradrenergic neurotransmitter system in 6-OHDA-induced amnesia and the favorable effect of adafenoxate on learning and memory impaired by 6-OHDA.
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
January 1985,
Psychopharmacology,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
January 1991,
Pharmacology, biochemistry, and behavior,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
April 1999,
Alcoholism, clinical and experimental research,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
July 1982,
Behavioral and neural biology,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
February 2002,
Psychopharmacology,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
September 1971,
European journal of pharmacology,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
November 2001,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
June 2002,
The Journal of pharmacology and experimental therapeutics,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
July 1978,
Psychopharmacology,
M G Genkova-Papazova, and
S L Stancheva, and
L G Alova, and
M B Lazarova-Bakarova
May 1998,
Neuroscience letters,
