BIOMAT Database Logo BIOMAT Database Logo

Surveillance in hereditary nonpolyposis colorectal cancer: an international cooperative study of 165 families. The International Collaborative Group on HNPCC. 1993

H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands.

During its second meeting at Amsterdam in 1990, the International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) decided to carry out a pilot study on colorectal cancer surveillance in HNPCC. The objectives of the study were to ascertain in each of the participating centers the number of HNPCC families, the recommended screening procedures, the age at diagnosis of colorectal cancer (CRC), and the occurrence of interval cancers. Nine centers in seven countries including Denmark, Finland, Italy, Japan, The Netherlands, Switzerland, and the United States participated. Data were derived from a total of 165 families. With respect to screening, half of the centers advise colonoscopy as the only procedure. The interval between the consecutive examinations varies from one to three years. In the majority of the centers, screening begins at 20 to 25 years. Lifelong screening is recommended by three centers, while the rest advise discontinuation at age 60 to 75 years. The family material included 840 patients with colorectal cancer. The mean age at diagnosis was 45 years, and about 15 percent were diagnosed at age 60 or later. A total of 682 high-risk relatives are being followed. After the follow-up of 1 to 10 years in these families, only six cases of interval cancers were encountered.

UI MeSH Term Description Entries
D007391 International Cooperation The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest. Foreign Aid,Treaties,Aid, Foreign,Cooperation, International,Treaty
D008403 Mass Screening Organized periodic procedures performed on large groups of people for the purpose of detecting disease. Screening,Mass Screenings,Screening, Mass,Screenings,Screenings, Mass
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010865 Pilot Projects Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work. Pilot Studies,Pilot Study,Pilot Project,Project, Pilot,Projects, Pilot,Studies, Pilot,Study, Pilot
D011159 Population Surveillance Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy. Surveillance, Population
D003123 Colorectal Neoplasms, Hereditary Nonpolyposis A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer. Colon Cancer, Familial Nonpolyposis, Type 1,Colorectal Cancer, Hereditary Nonpolyposis, Type 1,Familial Nonpolyposis Colon Cancer Type 1,Hereditary Nonpolyposis Colorectal Cancer,Hereditary Nonpolyposis Colorectal Cancer Type 1,Hereditary Nonpolyposis Colorectal Neoplasms,Lynch Syndrome,Colon Cancer, Familial Nonpolyposis,Colorectal Cancer Hereditary Nonpolyposis,Familial Nonpolyposis Colon Cancer,Hereditary Nonpolyposis Colon Cancer,Lynch Cancer Family Syndrome I,Lynch Syndrome I,Syndrome, Lynch
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
Clinical and genetic features of International Collaborative Group-hereditary nonpolyposis colorectal cancer families and suspected hereditary nonpolyposis colorectal cancer families.
May 2004, Chinese medical journal,
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer.
October 1997, Gastroenterology,
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
Suspected hereditary nonpolyposis colorectal cancer: International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) criteria and results of genetic diagnosis.
June 1999, Diseases of the colon and rectum,
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
Hereditary nonpolyposis colorectal cancer (HNPCC).
January 1999, Cytogenetics and cell genetics,
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: Problems in diagnosis, surveillance, and management.
January 2004, Cancer,
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
[Clinical phenotype of Chinese hereditary nonpolyposis colorectal cancer (HNPCC) families].
January 2006, Zhonghua zhong liu za zhi [Chinese journal of oncology],
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch syndrome.
January 2013, Deutsches Arzteblatt international,
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
What is hereditary nonpolyposis colorectal cancer (HNPCC).
January 1994, Anticancer research,
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
[Mutation of human mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) families].
March 1999, Zhonghua zhong liu za zhi [Chinese journal of oncology],
H F Vasen, and J P Mecklin, and P Watson, and J Utsunomiya, and L Bertario, and P Lynch, and L B Svendsen, and G Cristofaro, and H Müller, and P M Khan
The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC)--results of an international collaborative study.
January 2001, Familial cancer,
Copied contents to your clipboard!