This review had two main objectives. The first goal was to attempt to define a final common pathway for traction retinal detachment. To illustrate this, I considered the following three common clinical entities: penetrating ocular trauma, proliferative vitreoretinopathy, and proliferative diabetic retinopathy. My second goal was to emphasize the role of research in developing a rational approach to treatment. To illustrate the second goal, I reviewed the contributions from three realms of research--laboratory, animal, and clinical research--examining their interactions and considering their roles in our current understanding and management of these clinical entities.