Biomaterial Database

Spontaneous corneal neovascularization in nude mice. Local imbalance between angiogenic and anti-angiogenic factors. 1993

G M Kaminska, and J Y Niederkorn

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-9057.

OBJECTIVE The present study considered the hypothesis that spontaneous neovascularization of the cornea of nude mice results from a local imbalance between angiogenic and anti-angiogenic factors. METHODS The presence of angiogenic and anti-angiogenic factors was revealed by exchanging orthotopic corneal allografts between nude BALB/c mice and normal (hirsute) euthymic BALB/c mice and observing the presence, intensity, and degree of corneal neovascularization before and after grafting. RESULTS Avascular corneal grafts from normal BALB/c donors resisted neovascularization after grafting to spontaneously vascularized graft beds in nude mice. In contrast, spontaneously vascularized corneal grafts from nude mice remained vascularized over 2 mo after grafting to similar nude recipients. Although corneal grafts from nude donors stimulated neovascularization in normal BALB/c recipients, most of the vessels regressed by the 6th week post transplantation. CONCLUSIONS The results confirm that there is an imbalance between angiogenic and anti-angiogenic factors in the nude mouse cornea. The cornea of the nude mouse displays more angiogenic activity and less anti-angiogenic activity than that of the normal mouse. Most angiogenic activity of the nude mouse cornea appears to reside in the epithelium.

UI	MeSH Term	Description	Entries
D008807	Mice, Inbred BALB C	An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.	BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008819	Mice, Nude	Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.	Athymic Mice,Mice, Athymic,Nude Mice,Mouse, Athymic,Mouse, Nude,Athymic Mouse,Nude Mouse
D003315	Cornea	The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)	Corneas
D004848	Epithelium	The layers of EPITHELIAL CELLS which cover the inner and outer surfaces of the cutaneous, mucus, and serous tissues and glands of the body.	Mesothelium,Epithelial Tissue,Mesothelial Tissue,Epithelial Tissues,Mesothelial Tissues,Tissue, Epithelial,Tissue, Mesothelial,Tissues, Epithelial,Tissues, Mesothelial
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014184	Transplantation, Homologous	Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.	Transplantation, Allogeneic,Allogeneic Grafting,Allogeneic Transplantation,Allografting,Homografting,Homologous Transplantation,Grafting, Allogeneic
D016039	Corneal Transplantation	Partial or total replacement of the CORNEA from one human or animal to another.	Grafting, Corneal,Keratoplasty,Keratoplasty, Lamellar,Transplantation, Corneal,Cornea Transplantation,Transplantation, Cornea,Cornea Transplantations,Corneal Grafting,Corneal Graftings,Corneal Transplantations,Graftings, Corneal,Keratoplasties,Keratoplasties, Lamellar,Lamellar Keratoplasties,Lamellar Keratoplasty,Transplantations, Cornea,Transplantations, Corneal
D016510	Corneal Neovascularization	New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.	Corneal Angiogenesis,Angiogenesis, Corneal,Corneal Neovascularizations,Neovascularization, Corneal,Neovascularizations, Corneal
D043925	Angiogenesis Inducing Agents	Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.	Angiogenesis Inducers,Angiogenesis Effect,Angiogenesis Effects,Angiogenesis Factor,Angiogenesis Stimulating Agents,Angiogenesis Stimulators,Angiogenic Factor,Tumor Angiogenic Factor,Agents, Angiogenesis Inducing,Agents, Angiogenesis Stimulating,Angiogenic Factor, Tumor,Effect, Angiogenesis,Effects, Angiogenesis,Factor, Angiogenesis,Factor, Angiogenic,Factor, Tumor Angiogenic,Inducers, Angiogenesis,Inducing Agents, Angiogenesis,Stimulating Agents, Angiogenesis,Stimulators, Angiogenesis