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A sixfold difference in resistance to coccidia (Eimeria tenella) infection between a resistant and a susceptible line of Auburn White Leghorn chickens, derived by selective breeding, has been reported. The purpose of the following study was to determine whether the resistance or susceptibility phenomenon in the Auburn lines could be manifested in a homogeneous group of isolated host kidney cells that support E. tenella development in vitro but not normally in vivo. Propagation of the parasite in host cells in vitro eliminates humoral and cellular elements of immunity, and allows the study of host genetic influences at the cellular level. Differences in parasite development were examined between the two lines of cells in vitro after 48 and 96 h of incubation; time periods that reflect initial infection of the host cells by the parasite and the subsequent asexual development. Quantification of differences by liquid scintillation counting was based on parasite-specific incorporation of pyrimidines, specifically [3H]-uracil. The results supported previous findings that overall E. tenella development was significantly greater in the host cells from the susceptible line than in the cells from the resistant cultures at both time periods.
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
February 1969,
Science (New York, N.Y.),
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
November 1973,
The Journal of protozoology,
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
December 1971,
The Journal of parasitology,
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
November 1976,
The Journal of protozoology,
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
January 1968,
Zeitschrift fur Parasitenkunde (Berlin, Germany),
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
November 1978,
The Journal of protozoology,
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
October 1980,
Poultry science,
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
April 1981,
Parasitology,
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
August 1976,
The Journal of protozoology,
K L Quist, and
R L Taylor, and
L W Johnson, and
R G Strout
October 1977,
Canadian journal of comparative medicine : Revue canadienne de medecine comparee,
