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The effect of the neuropeptides bombesin and vasoactive intestinal peptide, as well as neurotensin, on natural killer activity by lamina propria mononuclear cells isolated from histologically normal mucosa was assessed. Bombesin and vasoactive intestinal peptide were found to dose-dependently stimulate natural killer activity against Caco-2 colon carcinoma target cells, especially in a short incubation assay, whereas no alterations of cytotoxicity were found against K-562 target cells. Neurotensin, on the contrary, was not found to affect this type of cellular cytotoxicity. Differences in the modulatory effects of these gastrointestinal peptides on natural killer activity by lamina propria mononuclear cells may be related to the distinct localization differences of these peptides within the bowel. The present findings illustrate the existence of neuro-immune interactions at the intestinal mucosa level.
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
June 1982,
The Journal of experimental medicine,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
April 1997,
Gastroenterology,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
October 1991,
Gastroenterology,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
January 1992,
Gut,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
June 2005,
European journal of immunology,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
January 2011,
Annual review of physiology,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
December 2022,
STAR protocols,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
January 1999,
The Tohoku journal of experimental medicine,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
June 2010,
Nature reviews. Immunology,
E A van Tol, and
H W Verspaget, and
B E Hansen, and
C B Lamers
June 1983,
Annals of the New York Academy of Sciences,
