Local intra-arterial fibrinolytic therapy in patients with stroke: urokinase versus recombinant tissue plasminogen activator (r-TPA). 1993

H Zeumer, and H J Freitag, and F Zanella, and A Thie, and C Arning
Department of Neuroradiology, University Hospital Eppendorf, Hamburg, Federal Republic of Germany.

A group of 59 patients with stroke due to acute vertebrobasilar or carotid territory occlusion have been treated by local intra-arterial fibrinolysis (LIF). A high recanalisation rate was accomplished with either urokinase or recombinant tissue plasminogen activator (r-TPA). However, with either substance, even if a high dose was used, recanalisation was a time-consuming process which usually took 120 min. A reasonable explanation for the lack of effectiveness of these plasminogen-activating substances might be a deficit of substrate, e.g. plasminogen, in aged thrombus. LIF was capable of improving clinical outcome in acute vertebrobasilar artery occlusion, reducing mortality to 50% in patients fulfilling inclusion criteria. In the carotid territory multiple occlusions had a poor prognosis while good clinical results could be achieved in occlusions of the proximal middle cerebral artery or single branches.

UI MeSH Term Description Entries
D002341 Carotid Artery Thrombosis Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX. Thrombosis, Carotid Artery,Carotid Thrombosis,Common Carotid Artery Thrombosis,External Carotid Artery Thrombosis,Internal Carotid Artery Thrombosis,Thrombosis, Carotid,Thrombosis, Common Carotid Artery,Thrombosis, External Carotid Artery,Thrombosis, Internal Carotid Artery,Carotid Artery Thromboses
D002542 Intracranial Embolism and Thrombosis Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures. Brain Embolism and Thrombosis,Cerebral Embolism and Thrombosis,Embolism and Thrombosis, Brain
D002561 Cerebrovascular Disorders A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others. Brain Vascular Disorders,Intracranial Vascular Disorders,Vascular Diseases, Intracranial,Cerebrovascular Diseases,Cerebrovascular Insufficiency,Cerebrovascular Occlusion,Brain Vascular Disorder,Cerebrovascular Disease,Cerebrovascular Disorder,Cerebrovascular Insufficiencies,Cerebrovascular Occlusions,Disease, Cerebrovascular,Diseases, Cerebrovascular,Insufficiencies, Cerebrovascular,Insufficiency, Cerebrovascular,Intracranial Vascular Disease,Intracranial Vascular Diseases,Intracranial Vascular Disorder,Occlusion, Cerebrovascular,Occlusions, Cerebrovascular,Vascular Disease, Intracranial,Vascular Disorder, Brain,Vascular Disorder, Intracranial,Vascular Disorders, Brain,Vascular Disorders, Intracranial
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014568 Urokinase-Type Plasminogen Activator A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES. Plasminogen Activator, Urokinase-Type,U-Plasminogen Activator,Urinary Plasminogen Activator,Urokinase,Abbokinase,Kidney Plasminogen Activator,Renokinase,Single-Chain Urokinase-Type Plasminogen Activator,U-PA,Single Chain Urokinase Type Plasminogen Activator,U Plasminogen Activator,Urokinase Type Plasminogen Activator
D014715 Vertebrobasilar Insufficiency Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated. Basilar Artery Insufficiency,Basilar Artery Stenosis,Vertebral Artery Insufficiency,Vertebral Artery Stenosis,Basilar Artery Ischemia,Basilar Insufficiency,Vertebral Artery Ischemia,Vertebro-Basilar Insufficiency,Vertebro-Basilar Ischemia,Vertebrobasilar Dolichoectasia,Vertebrobasilar Ischemia,Artery Insufficiencies, Basilar,Artery Insufficiencies, Vertebral,Artery Insufficiency, Basilar,Artery Insufficiency, Vertebral,Artery Ischemia, Basilar,Artery Ischemia, Vertebral,Artery Ischemias, Basilar,Artery Ischemias, Vertebral,Artery Stenoses, Basilar,Artery Stenoses, Vertebral,Artery Stenosis, Basilar,Artery Stenosis, Vertebral,Basilar Artery Insufficiencies,Basilar Artery Ischemias,Basilar Artery Stenoses,Basilar Insufficiencies,Dolichoectasia, Vertebrobasilar,Dolichoectasias, Vertebrobasilar,Insufficiencies, Basilar,Insufficiencies, Basilar Artery,Insufficiencies, Vertebral Artery,Insufficiencies, Vertebro-Basilar,Insufficiencies, Vertebrobasilar,Insufficiency, Basilar,Insufficiency, Basilar Artery,Insufficiency, Vertebral Artery,Insufficiency, Vertebro-Basilar,Insufficiency, Vertebrobasilar,Ischemia, Basilar Artery,Ischemia, Vertebral Artery,Ischemia, Vertebro-Basilar,Ischemia, Vertebrobasilar,Ischemias, Basilar Artery,Ischemias, Vertebral Artery,Ischemias, Vertebro-Basilar,Ischemias, Vertebrobasilar,Stenoses, Basilar Artery,Stenoses, Vertebral Artery,Stenosis, Basilar Artery,Stenosis, Vertebral Artery,Vertebral Artery Insufficiencies,Vertebral Artery Ischemias,Vertebral Artery Stenoses,Vertebro Basilar Insufficiency,Vertebro Basilar Ischemia,Vertebro-Basilar Insufficiencies,Vertebro-Basilar Ischemias,Vertebrobasilar Dolichoectasias,Vertebrobasilar Insufficiencies,Vertebrobasilar Ischemias
D015641 Radiography, Interventional Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization. Interventional Radiography
D015912 Thrombolytic Therapy Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts. Fibrinolytic Therapy,Thrombolysis, Therapeutic,Therapeutic Thrombolysis,Therapy, Fibrinolytic,Therapy, Thrombolytic,Fibrinolytic Therapies,Therapeutic Thrombolyses,Therapies, Fibrinolytic,Therapies, Thrombolytic,Thrombolyses, Therapeutic,Thrombolytic Therapies

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