Biomaterial Database

Ophthalmological follow-up of diabetic patients after kidney transplantation. 1993

L Laatikainen, and P Summanen, and A Ekstrand, and L Groop

Department of Ophthalmology, University of Helsinki, Finland.

Visual acuity (VA) and changes in diabetic retinopathy after kidney transplantation were prospectively evaluated in 29 patients with type 1 diabetes. At the time of transplantation, 9 patients (31%) had background retinopathy (RP) and 20 patients (69%) had proliferative RP in one eye or both eyes. During the follow-up period of 0.5-4 years (median, 3.0 years), background RP remained stable in 13 of 22 eyes (59.1%), improved in 6 eyes (27.3%) and changed to proliferative RP in 3 eyes (13.6%). Of the 26 eyes with proliferative RP, proliferative changes decreased in 6 (23.1%) and increased in 4 (15.4%). Initially 11 eyes were blind (VA less than counting fingers at 1 m), and in 1 of them the VA improved after vitrectomy. In 42 of the remaining 47 eyes (89.4%) the VA remained unchanged (within 2 lines better or worse), in 4 eyes (8.5%) it improved and in 1 eye (2.1%) it deteriorated. Five patients died during the follow-up period. These results indicate that in most diabetic patients, retinopathy remains stable or improves after kidney transplantation, but regular ophthalmological follow-up is important for the discovery of eyes in which further treatment is indicated.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011379	Prognosis	A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.	Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D012160	Retina	The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.	Ora Serrata
D003922	Diabetes Mellitus, Type 1	A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.	Diabetes Mellitus, Brittle,Diabetes Mellitus, Insulin-Dependent,Diabetes Mellitus, Juvenile-Onset,Diabetes Mellitus, Ketosis-Prone,Diabetes Mellitus, Sudden-Onset,Diabetes, Autoimmune,IDDM,Autoimmune Diabetes,Diabetes Mellitus, Insulin-Dependent, 1,Diabetes Mellitus, Type I,Insulin-Dependent Diabetes Mellitus 1,Juvenile-Onset Diabetes,Type 1 Diabetes,Type 1 Diabetes Mellitus,Brittle Diabetes Mellitus,Diabetes Mellitus, Insulin Dependent,Diabetes Mellitus, Juvenile Onset,Diabetes Mellitus, Ketosis Prone,Diabetes Mellitus, Sudden Onset,Diabetes, Juvenile-Onset,Diabetes, Type 1,Insulin Dependent Diabetes Mellitus 1,Insulin-Dependent Diabetes Mellitus,Juvenile Onset Diabetes,Juvenile-Onset Diabetes Mellitus,Ketosis-Prone Diabetes Mellitus,Sudden-Onset Diabetes Mellitus
D003930	Diabetic Retinopathy	Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.	Diabetic Retinopathies,Retinopathies, Diabetic,Retinopathy, Diabetic
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man