BIOMAT Database Logo BIOMAT Database Logo

Differences of intravenous nitroglycerin responses in left ventricular systolic and end-diastolic pressures and coronary artery diameters during long-term treatment with cutaneous nitroglycerin patches. 1993

H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Saiseikai Yamaguchi General Hospital, Japan.

The differences of intravenous nitroglycerin responses in left ventricular (LV) systolic and end-diastolic pressures and in coronary artery diameters (cross-tolerance) were investigated in patients receiving nitroglycerin patches. During diagnostic cardiac catheterization, graded doses of 50, 100, and 150 mcg of intravenous nitroglycerin were given. Left ventricular systolic and end-diastolic pressures and left coronary arteriograms were obtained during each dose. Twenty patients with coronary artery disease were studied. Before cardiac catheterization, 10 received nitroglycerin patch (patch group), and 10 did not (control group). In the control group, graded intravenous nitroglycerin doses of 50, 100, and 150 mcg caused decrease in LV systolic pressure of 18 +/- 7%, 20 +/- 5%, and 23 +/- 6%, respectively. In the patch group, the same intravenous nitroglycerin doses decreased LV systolic pressure by 12 +/- 6% (p < 0.05), 19 +/- 7% (NS), and 18 +/- 6% (p < 0.05), respectively, (p value: vs. control group). At the same intravenous nitroglycerin doses, LV end-diastolic pressures were decreased by 48 +/- 14%, 52 +/- 17%, and 56 +/- 9%, respectively, in the control group. However, there were no significant differences in LV end-diastolic pressure between the two groups for any of the three intravenous nitroglycerin doses. The same intravenous nitroglycerin doses caused increase in diameter of the left anterior descending coronary artery and circumflex coronary artery in the control group, which was attenuated significantly in the patch group. Tolerance may develop in LV systolic pressure and coronary artery diameters, whereas it may not develop in LV end-diastolic pressure.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002407 Catheterization, Swan-Ganz Placement of a balloon-tipped catheter into the pulmonary artery through the antecubital, subclavian, and sometimes the femoral vein. It is used to measure pulmonary artery pressure and pulmonary artery wedge pressure which reflects left atrial pressure and left ventricular end-diastolic pressure. The catheter is threaded into the right atrium, the balloon is inflated and the catheter follows the blood flow through the tricuspid valve into the right ventricle and out into the pulmonary artery. Catheterization, Pulmonary Artery,Swan-Ganz Catheterization,Pulmonary Artery Catheterization,Artery Catheterization, Pulmonary,Artery Catheterizations, Pulmonary,Catheterization, Swan Ganz,Catheterizations, Pulmonary Artery,Pulmonary Artery Catheterizations,Swan Ganz Catheterization
D003331 Coronary Vessels The veins and arteries of the HEART. Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D004361 Drug Tolerance Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL. Drug Tolerances,Tolerance, Drug,Tolerances, Drug
D005260 Female Females
D005996 Nitroglycerin A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. Glyceryl Trinitrate,Anginine,Dynamite,Gilustenon,Nitrangin,Nitro-Bid,Nitro-Dur,Nitrocard,Nitroderm,Nitroderm TTS,Nitroglyn,Nitrol,Nitrolan,Nitrong,Nitrospan,Nitrostat,Perlinganit,Susadrin,Sustac,Sustak,Sustonit,Transderm Nitro,Tridil,Trinitrin,Trinitrolong,Nitro Bid,Nitro Dur,NitroBid,NitroDur,Trinitrate, Glyceryl

Related Publications

H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Left ventricular end-diastolic pressures following selective coronary arteriography.
November 1972, American heart journal,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
[Effects of nitroglycerin on left ventricular systolic, diastolic and regional myocardial function in patients with coronary artery disease].
June 1985, Journal of cardiography,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Relation of coronary artery disease and left ventricular systolic dysfunction to left ventricular end-diastolic pressure after left ventriculography.
June 1985, The American journal of cardiology,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Relation of coronary artery disease or left ventricular systolic function to post-angio left ventricular end-diastolic pressure.
January 1988, Indian heart journal,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Left ventricular systolic and diastolic function during acute coronary artery balloon occlusion in humans.
August 1988, Journal of the American College of Cardiology,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Coronary artery vasospasm during treatment with intravenous nitroglycerin.
January 1985, Catheterization and cardiovascular diagnosis,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Comparison of pulmonary artery diastolic and left ventricular end-diastolic pressures in patients with ischaemic heart disease.
July 1971, British heart journal,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Comparison of pulmonary artery diastolic and left ventricular end diastolic pressures in patients with ischaemic heart disease.
March 1972, Cardiovascular research,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Effects of intravenous magnesium chloride reverse left ventricular end-diastolic pressure in coronary artery disease.
March 1996, The American journal of cardiology,
H Naito, and Y Matsuda, and T Yorozu, and T Maeda, and T Tada, and K Shiomi
Relationship of the pulmonary artery end-diastolic pressure to the left ventricular end-diastolic and mean filling pressures in patients with and without left ventricular dysfunction.
July 1970, Circulation,
Copied contents to your clipboard!