The pulmonary autograft for aortic valve replacement in the young. 1993

E H Austin
Department of Surgery, University of Louisville School of Medicine, KY.

Until recently, a mechanical prosthesis has been the substitute valve of choice for children and young adults who require aortic valve replacement. The preference for using mechanical valves in this group resulted from the discovery that porcine valves experienced accelerated structural degeneration in the young. Unfortunately, mechanical valves impose a constant risk of thromboembolism, resulting in a lifelong requirement for anticoagulant therapy. Thus, young patients with the potential for longer survival face a higher likelihood of having a thromboembolic or hemorrhagic event. To provide young patients with a durable replacement aortic valve that is not thrombogenic and does not require anticoagulation, some cardiac surgeons are transferring the patient's own pulmonary valve to the aortic position and replacing the pulmonary valve with a cryopreserved valve (a homograft) from a cadaveric donor. Long-term follow-up of the experience of Mr Donald Ross of London, England, who introduced this operation in 1967, indicates that the pulmonary autograft has the best event-free survival of any form of aortic valve replacement. The technical demands of this operation are greater than those for routine aortic valve replacement with a mechanical prosthesis; however, the pulmonary autograft can be performed at an acceptably low risk. As more experience is acquired with this technique, it may become the preferred procedure for aortic valve replacement in the young.

UI MeSH Term Description Entries
D008297 Male Males
D011664 Pulmonary Valve A valve situated at the entrance to the pulmonary trunk from the right ventricle. Pulmonary Valves,Valve, Pulmonary,Valves, Pulmonary
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D006330 Heart Defects, Congenital Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life. Congenital Heart Disease,Heart Abnormalities,Abnormality, Heart,Congenital Heart Defect,Congenital Heart Defects,Defects, Congenital Heart,Heart Defect, Congenital,Heart, Malformation Of,Congenital Heart Diseases,Defect, Congenital Heart,Disease, Congenital Heart,Heart Abnormality,Heart Disease, Congenital,Malformation Of Heart,Malformation Of Hearts
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001021 Aortic Valve The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle. Aortic Valves,Valve, Aortic,Valves, Aortic
D013536 Suture Techniques Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES). Suture Technics,Suture Technic,Suture Technique,Technic, Suture,Technics, Suture,Technique, Suture,Techniques, Suture
D014182 Transplantation, Autologous Transplantation of an individual's own tissue from one site to another site. Autografting,Autologous Transplantation,Autotransplantation,Autograftings,Autologous Transplantations,Autotransplantations,Transplantations, Autologous

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