BIOMAT Database Logo BIOMAT Database Logo

Serum levels of placental protein 14 do not accurately reflect histologic maturation of the endometrium. 1993

M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.

OBJECTIVE To determine whether serum levels of placental protein 14, a major product of the progesterone-induced secretory endometrium, accurately reflect histologic maturation of the endometrium. METHODS Daily serum levels of placental protein 14 were compared in 50 normally cycling women with normal or delayed endometrial maturation, as assessed by histologic dating of an endometrial biopsy in the midluteal phase of the same cycle. Ten of these subjects had placental protein 14 measurements but no biopsy in an additional cycle to examine the potential effects of the biopsy on secretion of this protein. RESULTS Serum placental protein 14 concentrations started to increase 8 days after the LH surge and peaked at similar levels on the first day of the next menses in biopsy and non-biopsy cycles. The biopsy cycles had a shorter luteal phase but a slightly faster increase in placental protein 14 concentrations. Both the integrated secretion of this protein and single measurements on the day of the biopsy or at the onset of the next menses overlapped substantially in women with different degrees of endometrial development, even when differentiation of the endometrium was severely delayed. CONCLUSIONS Serum measurements of placental protein 14 do not accurately predict, and thus should not replace, histologic evaluation of the endometrium at nidation.

UI MeSH Term Description Entries
D007247 Infertility, Female Diminished or absent ability of a female to achieve conception. Sterility, Female,Sterility, Postpartum,Sub-Fertility, Female,Subfertility, Female,Female Infertility,Female Sterility,Female Sub-Fertility,Female Subfertility,Postpartum Sterility,Sub Fertility, Female
D008183 Luteal Phase The period in the MENSTRUAL CYCLE that follows OVULATION, characterized by the development of CORPUS LUTEUM, increase in PROGESTERONE production by the OVARY and secretion by the glandular epithelium of the ENDOMETRIUM. The luteal phase begins with ovulation and ends with the onset of MENSTRUATION. Menstrual Cycle, Luteal Phase,Menstrual Cycle, Secretory Phase,Menstrual Secretory Phase,Postovulatory Phase,Phase, Luteal,Phase, Postovulatory,Secretory Phase, Menstrual
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011257 Pregnancy Proteins Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.) Placental Proteins,Proteins, Placental,Proteins, Pregnancy
D011863 Radioimmunoassay Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation. Radioimmunoassays
D004717 Endometrium The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo. Endometria
D005260 Female Females
D006023 Glycoproteins Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins. C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated

Related Publications

M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Do serum fructosamine levels accurately reflect levels of glycated albumin?
November 1987, Annals of clinical biochemistry,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Serum levels of placental protein 14 reflect ovulation in nonconceptional menstrual cycles.
January 1986, Fertility and sterility,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Secretory endometrium synthesizes placental protein 14.
May 1986, Endocrinology,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Serum fragmented cytokeratin 18 levels reflect the histologic activity score of nonalcoholic fatty liver disease more accurately than serum alanine aminotransferase levels.
July 2010, Journal of clinical gastroenterology,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
When keratometric measurements do not accurately reflect corneal topography.
January 1993, Journal of cataract and refractive surgery,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Serum alkaline phosphatase levels accurately reflect cholestasis in mice.
September 2015, Hepatology (Baltimore, Md.),
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Serum Levels of Progranulin Do Not Reflect Cerebrospinal Fluid Levels in Neurodegenerative Disease.
January 2016, Current Alzheimer research,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Responses to post-graduation surveys do not accurately reflect the workforce.
August 2017, Medical teacher,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Serum thyroid hormone levels may not accurately reflect thyroid tissue levels and cardiac function in mild hypothyroidism.
May 2008, American journal of physiology. Heart and circulatory physiology,
M C Batista, and N Bravo, and T P Cartledge, and D L Loriaux, and G R Merriam, and L K Nieman
Serum placental protein 14 (PP14) levels in patients with threatened abortion.
January 1996, Archives of gynecology and obstetrics,
Copied contents to your clipboard!