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The aim of this study was to test the efficacy of captopril, an angiotensin-converting enzyme inhibitor and a known suppressor of fibrosis, in preventing late radiation-induced cardiac pathology. Myocardial functional, histochemical and ultrastructural-morphometric studies were done on perfused hearts of rats isolated 3 and 6 months after 60Co gamma irradiation with 20 Gy and age-matched controls. At each time the animals were divided into the following groups: nonirradiated controls; irradiated once with 20 Gy; irradiated as above and given daily doses of captopril; daily doses of captopril without irradiation. The results showed that captopril, while ameliorating the decrease in the indices of capillary function, increase in mast cells, fibrosis, number of atrial granules, and changes in nerve terminals, failed to prevent the progressive functional deterioration of the hearts after irradiation. These findings suggest that an intramyofiber derangement may be involved in the long-term myocardial complications of irradiation.
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
April 2008,
Sheng li xue bao : [Acta physiologica Sinica],
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
September 1997,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
June 2013,
Journal of molecular and cellular cardiology,
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
October 1986,
British journal of clinical pharmacology,
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
January 1998,
Kidney international,
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
January 1995,
Pharmacological research,
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
February 1989,
BMJ (Clinical research ed.),
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
March 1993,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
March 1999,
Pharmacological research,
R Yarom, and
I S Harper, and
S Wynchank, and
D van Schalkwyk, and
J Madhoo, and
K Williams, and
R Salie, and
S Genade, and
A Lochner
May 2000,
Journal of immunology (Baltimore, Md. : 1950),
