BIOMAT Database Logo BIOMAT Database Logo

Brequinar sodium suppresses liver allograft rejection and induces permanent tolerance in the rat. 1993

M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California.

UI MeSH Term Description Entries
D007108 Immune Tolerance The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. Immunosuppression (Physiology),Immunosuppressions (Physiology),Tolerance, Immune
D007165 Immunosuppression Therapy Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs. Antirejection Therapy,Immunosuppression,Immunosuppressive Therapy,Anti-Rejection Therapy,Therapy, Anti-Rejection,Therapy, Antirejection,Anti Rejection Therapy,Anti-Rejection Therapies,Antirejection Therapies,Immunosuppression Therapies,Immunosuppressions,Immunosuppressive Therapies,Therapies, Immunosuppression,Therapies, Immunosuppressive,Therapy, Immunosuppression,Therapy, Immunosuppressive
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D011912 Rats, Inbred ACI An inbred strain of rat that is widely used in BIOMEDICAL RESEARCH. Applications include the study of spontaneous NEOPLASMS; CHRONIC KIDNEY DISEASES, and CONGENITAL ABNORMALITIES. Rats, Inbred A x C 9935 Irish,Rats, ACI,ACI Rat,ACI Rat, Inbred,ACI Rats,ACI Rats, Inbred,Inbred ACI Rat,Inbred ACI Rats,Rat, ACI,Rat, Inbred ACI
D011914 Rats, Inbred BN An inbred strain of rat that is widely used in a variety of research areas such as the study of ASTHMA; CARCINOGENESIS; AGING; and LEUKEMIA. Rats, Inbred Brown Norway,Rats, BN,BN Rat,BN Rat, Inbred,BN Rats,BN Rats, Inbred,Inbred BN Rat,Inbred BN Rats,Rat, BN,Rat, Inbred BN
D011917 Rats, Inbred Lew An inbred strain of rat that is used in BIOMEDICAL RESEARCH. Rats, Inbred Lewis,Rats, Lew,Inbred Lew Rat,Inbred Lew Rats,Inbred Lewis Rats,Lew Rat,Lew Rat, Inbred,Lew Rats,Lew Rats, Inbred,Lewis Rats, Inbred,Rat, Inbred Lew,Rat, Lew
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections
D006085 Graft Survival The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host. Graft Survivals,Survival, Graft,Survivals, Graft
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001713 Biphenyl Compounds Whitish aromatic crystalline organic compounds made up of two conjoined BENZENE rings. Compounds, Biphenyl

Related Publications

M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Brequinar sodium effectively and potently suppresses allograft rejection in a heterotopic mouse heart transplant model.
June 1993, Transplantation proceedings,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Use of brequinar sodium for preventing cardiac allograft rejection in primates.
June 1993, Transplantation proceedings,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Prevention of vascularized allograft and xenograft rejection in rodents by brequinar sodium.
June 1993, Transplantation proceedings,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
The synergism of brequinar sodium and cyclosporine used in combination to prevent cardiac allograft rejection in the rat.
September 1993, Transplantation,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Effect of brequinar sodium on accelerated cardiac allograft rejection in presensitized recipients.
August 1994, Transplantation proceedings,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Effective suppression of brequinar sodium on accelerated allograft rejection in presensitized recipients.
February 1995, Transplantation proceedings,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Evaluation of the use of brequinar sodium and cyclosporine combination therapy for preventing rat cardiac allograft rejection.
June 1993, Transplantation proceedings,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Levels of cytokine expression in rat liver allograft rejection compared to allograft tolerance.
October 1992, Transplantation proceedings,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
The prevention of accelerated cardiac allograft rejection in sensitized recipients after treatment with brequinar sodium.
October 1993, Transplantation,
M Knoop, and D V Cramer, and F C Chapman, and L Makowka
Gadolinium chloride suppresses acute rejection and induces tolerance following rat liver transplantation by inhibiting Kupffer-cell activation.
December 2014, Experimental and therapeutic medicine,
Copied contents to your clipboard!