Biomaterial Database

Mechanism of increased susceptibility to infection following hemorrhage. 1993

I H Chaudry, and A Ayala

Department of Surgery, Michigan State University, East Lansing 48824.

Although hemorrhage is known to cause increased susceptibility to infection, the precise mechanism remains unknown. Regional hypoxia due to reduced blood flow following hemorrhage appears to be a primary mediator that initiates the cascade of events leading to immunodepression and increased susceptibility to infection. This was evident from depression of lymphocyte functions, production of various lymphokines, macrophage expression of receptors involved in opsonin-mediated phagocytosis, and antigen presentation function of peritoneal, splenic, and Kupffer cells following hemorrhage. The depression in various immune functions is apparent immediately after hemorrhage and persists for a prolonged period of time, despite volume resuscitation. Furthermore, it appears that the increased release of systemic mediators, such as interleukin-1 (IL-1), IL-6, tumor necrosis factor, transforming growth factor type beta, and prostaglandin E2 is associated with marked depression in immune responses and increased susceptibility to infection following hemorrhage.

UI	MeSH Term	Description	Entries
D007111	Immunity, Cellular	Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.	Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D004198	Disease Susceptibility	A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.	Diathesis,Susceptibility, Disease,Diatheses,Disease Susceptibilities,Susceptibilities, Disease
D004731	Endotoxins	Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.	Endotoxin
D006470	Hemorrhage	Bleeding or escape of blood from a vessel.	Bleeding,Hemorrhages
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001424	Bacterial Infections	Infections by bacteria, general or unspecified.	Bacterial Disease,Bacterial Infection,Infection, Bacterial,Infections, Bacterial,Bacterial Diseases
D018407	Bacterial Physiological Phenomena	Physiological processes and properties of BACTERIA.	Bacterial Physiology,Bacterial Processes,Bacterial Physiological Concepts,Bacterial Physiological Phenomenon,Bacterial Process,Physiology, Bacterial,Bacterial Physiological Concept,Concept, Bacterial Physiological,Concepts, Bacterial Physiological,Phenomena, Bacterial Physiological,Phenomenon, Bacterial Physiological,Process, Bacterial,Processes, Bacterial