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To contribute to the undecided question if a retrovirus of the human T-cell lymphotropic virus (HTLV) family may be involved in the development of multiple sclerosis (MS), we investigated by the polymerase chain reaction (PCR) the presence of HTLV-I and HTLV-II sequences in the peripheral blood mononuclear cell DNAs from 30 patients affected by MS and 15 by chronic progressive myelopathy. Moreover a control group of 14 blood donors was examined. All these patients were devoid of anti-HTLV-I antibody in the serum and cerebrospinal fluid at ELISA. For the PCR, primers and probes specific for the tax region common to HTLV-I and HTLV-II, for the pol region of HTLV-I, and for the pol region of HTLV-II were used. In spite of the high sensitivity of the technique used, the three groups of subjects were negative for HTLV-I and HTLV-II genomic sequences.
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
October 1988,
Presse medicale (Paris, France : 1983),
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
June 1989,
Asian Pacific journal of allergy and immunology,
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
December 1988,
Acta neurologica,
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
February 1999,
Journal of neurovirology,
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
July 1991,
Lancet (London, England),
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
October 1986,
Annals of neurology,
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
January 2020,
Multiple sclerosis and related disorders,
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
November 1988,
Journal of the neurological sciences,
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
June 1987,
Italian journal of neurological sciences,
E Merelli, and
P Sola, and
R Marasca, and
R Salati, and
G Torelli
November 1992,
The Clinical investigator,
