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The antitumor effect of rubratoxin B, a mycotoxin, has been studied. Yoshida ascites sarcoma cells, in vitro in contact for 30 min with the drug and injected immediately afterwards into young rats by the intraperitoneal route, produced the survival of 80% of the animals and the doubling of the median survival time of the rats developing neoplasia. In vivo administration of the drug by the intraperitoneal route 24 h after implantation of tumor cells determined the prolongation of median survival time; supplied by other routes both against T8 sarcoma of Guérin and Yoshida ascites sarcoma it was ineffective. The differences between in vitro and in vivo results can be explained by a rapid neutralization of the drug on behalf of the organism's enzymes or by being bound to proteins and peritoneal cells unlike tumor cells.
V Fimiani, and
A Richetti
August 1973,
Antimicrobial agents and chemotherapy,
V Fimiani, and
A Richetti
February 1977,
Food and cosmetics toxicology,
V Fimiani, and
A Richetti
March 1979,
Mycopathologia,
V Fimiani, and
A Richetti
June 1976,
Bulletin of environmental contamination and toxicology,
V Fimiani, and
A Richetti
August 1968,
Applied microbiology,
V Fimiani, and
A Richetti
May 1968,
Chemistry & industry,
V Fimiani, and
A Richetti
May 1973,
Research communications in chemical pathology and pharmacology,
V Fimiani, and
A Richetti
January 1977,
Toxicology and applied pharmacology,
V Fimiani, and
A Richetti
April 1974,
Bulletin of environmental contamination and toxicology,
