-transparent.png){kind=logo}
We describe two children who had central nervous system complications, encephalitis and meningoencephalitis, temporally associated with Mycoplasma pneumoniae. M pneumoniae was identified as the cause of the illnesses on the basis of at least a fourfold increase in complement fixation antibody titers. Despite extensive viral and bacterial investigation, no evidence of any other pathogen was found. Two strategies were used to determine whether M pneumoniae was directly invasive: (1) by examining cerebrospinal fluid using a M pneumoniae-specific DNA probe and (2) by determining whether complement-fixating antibody to M pneumoniae was produced locally through comparison of the cerebrospinal fluid/serum ratio of M pneumoniae antibody to the cerebrospinal fluid/serum ratio of immunoglobulin M. Both assessments were negative. M pneumoniae did not appear to directly invade the central nervous system in these two patients. We conclude that the direct invasion of the cerebrospinal fluid is not necessary in the pathogenesis of M pneumoniae-induced neurologic disease.
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
January 1969,
Scandinavian journal of infectious diseases,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
August 1972,
Archives of internal medicine,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
August 2004,
Pediatric neurology,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
October 1980,
Journal of neurology, neurosurgery, and psychiatry,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
January 1980,
Scandinavian journal of infectious diseases,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
January 1979,
Acta medica Scandinavica,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
January 1983,
The Yale journal of biology and medicine,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
August 2005,
The Journal of laboratory and clinical medicine,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
September 2001,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
C V Fernandez, and
R Bortolussi, and
K Gordon, and
S H Lee, and
J G Gatien, and
M S Shahdrabadi
August 2006,
Current opinion in neurology,
