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The effect of uremia on skeletal muscle metabolism of the rat was examined using 31P-magnetic resonance spectroscopy. Three weeks following either a 5/6 nephrectomy or a sham operation, Wistar rats were placed in a 7T magnet, and the sciatic nerve was stimulated for 10 min. Analysis of spectra allowed calculation of intracellular pH and the relative concentrations of phosphocreatine (PCr), inorganic phosphate (Pi) and ATP. [ADP] was calculated from the creatine kinase equilibrium. There was a significant reduction in the resting intracellular [Pi] despite an elevation in extracellular [Pi], probably due to a reduction in the activity of the membrane Na/Pi cotransporter on account of a reduced sodium gradient. Despite anemia and uremia, there were no significant metabolic abnormalities during exercise and recovery accompanying this substantial reduction in glomerular filtration rate implying that at this level of renal impairment, there is no mitochondrial dysfunction.
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
October 1997,
Brain : a journal of neurology,
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
December 1990,
Clinical science (London, England : 1979),
C H Thompson, and
G J Kemp, and
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L K Rix, and
G K Radda, and
J G Ledingham
January 1993,
Nephron,
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
September 1984,
Biochimica et biophysica acta,
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
March 1994,
Critical care medicine,
C H Thompson, and
G J Kemp, and
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L K Rix, and
G K Radda, and
J G Ledingham
July 1993,
Clinical science (London, England : 1979),
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
October 1992,
Canadian journal of physiology and pharmacology,
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
May 1991,
Canadian journal of physiology and pharmacology,
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
October 1992,
The Journal of rheumatology,
C H Thompson, and
G J Kemp, and
Y S Green, and
L K Rix, and
G K Radda, and
J G Ledingham
February 1993,
The Journal of clinical investigation,
