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In a prospective study 3 x 5000 IU sodium heparin s.c. have been used for the prevention of postoperative deep vein thrombosis. Prevention started preoperatively in general surgical and urological patients. The diagnosis was made in all cases by means of the iodine 125fibrinogen test. In 2 out of 22 patients with a correct protocol deep vein thrombosis was diagnosed. 4 patients showed bleeding complications, in 2 of them heparin had to be stopped. A review of the world literature reveals that heparin prevention has been tested in general surgery in 2253 patients. The incidence of deep vein thrombosis was 8.6% compared to 28% in the controls. In orthopedic surgery only 279 patients are documented, the deep vein thrombosis frequency dropped from 46% to 22.2%. The results are contradictory. Both in urology and gynecology only few patients have been studied, definite conclusions are therefore not possible. The number of fatal pulmonary emboli in about 4000 patients under heparin prevention was 0.2%, in a control group of similar size 0.8%. This difference is statistically significant.
E M Matt, and
U F Gruber
January 1986,
Medecine interne,
E M Matt, and
U F Gruber
March 1976,
Nederlands tijdschrift voor geneeskunde,
E M Matt, and
U F Gruber
September 1984,
Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti,
E M Matt, and
U F Gruber
January 1978,
La Nouvelle presse medicale,
E M Matt, and
U F Gruber
January 1976,
Nederlands tijdschrift voor geneeskunde,
E M Matt, and
U F Gruber
May 1983,
Khirurgiia,
E M Matt, and
U F Gruber
August 1961,
Nordisk medicin,
E M Matt, and
U F Gruber
July 1978,
Nederlands tijdschrift voor geneeskunde,
E M Matt, and
U F Gruber
January 1984,
Revista de chirurgie, oncologie, radiologie, o.r.l., oftalmologie, stomatologie. Chirurgie,
E M Matt, and
U F Gruber
December 1972,
La Nouvelle presse medicale,
