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A genetic linkage map of human chromosome 1 based entirely on PCR-typable markers has been developed using 38 simple sequence repeat (SSR) polymorphisms. These SSRs include 36 dinucleotide repeats and 2 tetranucleotide repeats. The average heterozygosity at these markers was 0.73 and ranged from 0.52 to 0.95. Multipoint linkage analysis was used to develop a map of these 38 markers in which the relative placement of each locus is supported by likelihood odds > 1000:1. This PCR-based map was anchored at the centromere by the D1Z5 alpha-satellite polymorphism, and the ends of the map were defined by D1Z2 and D1S68, which are the most distal loci in the CEPH consortium map of chromosome 1. The sex-averaged, male, and female maps extend for 328, 273, and 409 cM, respectively. The average distance between markers on the sex-averaged map is 8 cM, and the largest interval is 32 cM. This map of highly informative PCR-based markers will provide a rapid means of screening human chromosome 1 for the presence of disease genes.
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
July 1994,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
April 1991,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
December 1994,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
July 1995,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
November 1992,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
August 1988,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
November 2003,
Annals of human genetics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
June 1993,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
January 1993,
Genomics,
M Engelstein, and
T J Hudson, and
J M Lane, and
M K Lee, and
B Leverone, and
G M Landes, and
L Peltonen, and
J L Weber, and
N C Dracopoli
January 1993,
Genomics,
