Biomaterial Database

Tissue and serum concentrations of ofloxacin in the ear region following a single daily oral dose of 400 mg. 1993

P Tolsdorff

HNO-Abteilung am Kath. Krankenhaus im Siebengebirge, Bad Honnef, Germany.

Even after a single daily dose of 400 mg, the concentrations of ofloxacin in infected middle ear tissues are within the therapeutic range. Even 20 h after a single dose of 400 mg ofloxacin, the tissue concentrations in cartilage and cholesteatomatous matrix are in excess of the minimal inhibitory concentration for a number of pathogens, such as Staphylococcus aureus and Haemophilus influenzae. The especially high concentrations in middle ear mucosa, auricular cartilage and cholesteatomatous matrix are striking. No complications or side effects were observed during ofloxacin treatment in this study. The study demonstrates that a dose of 400 mg ofloxacin per day is an effective and patient orientated therapeutic regime for the treatment of ENT infections, particularly of ear infections.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008416	Mastoid	The posterior part of the temporal bone. It is a projection of the petrous bone.	Mastoid Foramen,Mastoid Bone,Mastoid Process,Bone, Mastoid,Foramen, Mastoid,Mastoid Bones,Mastoid Processes,Mastoids,Process, Mastoid
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D004334	Drug Administration Schedule	Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.	Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004425	Ear Cartilage	Cartilage of the EAR AURICLE and the EXTERNAL EAR CANAL.	Auricular Cartilage,Ear Cartilages,External Ear Cartilage,Auricular Cartilages,Cartilage, Auricular,Cartilage, Ear,Cartilage, External Ear,Cartilages, Auricular,Cartilages, Ear,Cartilages, External Ear,External Ear Cartilages
D004432	Ear, Middle	The space and structures directly internal to the TYMPANIC MEMBRANE and external to the inner ear (LABYRINTH). Its major components include the AUDITORY OSSICLES and the EUSTACHIAN TUBE that connects the cavity of middle ear (tympanic cavity) to the upper part of the throat.	Tympanic Cavity,Tympanum,Middle Ear,Cavities, Tympanic,Cavity, Tympanic,Ears, Middle,Middle Ears,Tympanic Cavities,Tympanums
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations