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By the use of flow cytometry, 17 patients with chronic granulomatous disease (CGD) were examined for lymphocyte subsets. CD4+CD29+ cell (memory T cell) and CD8+CD11b+ cell (suppressor T cell) subsets in CGD were significantly decreased and remained practically unchanged throughout the period examined except in those < 6 months of age, although in controls both subsets gradually increased with age. These data indicate a certain abnormality in the maturation process of CGD T lymphocytes. Memory T cells are known to secrete a large amount of interferon-gamma (IFN-gamma). Recently, administration of IFN-gamma to CGD patients has become an effective treatment that reduces the frequency of serious bacterial infections. Decreased memory T cells may clarify the mechanism of therapeutic effectiveness, which remains unknown.
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
November 2002,
The Journal of clinical investigation,
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
December 2021,
Journal of immunology (Baltimore, Md. : 1950),
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
January 1998,
Archives of environmental health,
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
January 1991,
Dermatologica,
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
July 1994,
Journal of acquired immune deficiency syndromes,
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
January 1991,
Clinical and experimental immunology,
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
August 1998,
Clinical immunology and immunopathology,
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
December 2002,
Clinical immunology (Orlando, Fla.),
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
June 2014,
Iranian journal of allergy, asthma, and immunology,
M Hasui, and
K Hattori, and
S Taniuchi, and
U Kohdera, and
A Nishikawa, and
Y Kinoshita, and
Y Kobayashi
January 2017,
Frontiers in immunology,
