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The mechanisms of erythromycin (EM) in chronic lower respiratory tract diseases including diffuse panbronchiolitis (DPB) has been reported. In this study we investigated the effect of EM on peripheral neutrophil adhesion molecules such as LFA-1 and Mac-1 obtained from six healthy subjects. Pretreatment of neutrophils with each concentration (10 ng/ml approximately 100 micrograms/ml) of EM resulted in no significant reduction in the expression of LFA-1 alpha, beta and Mac-1. Moreover, EM had no capability of reducing these expressions even when neutrophils were pretreated with 1 microgram/ml of EM at time from 0 to 60 min. These findings indicate that EM does not directly reduce the expression of LFA-1 alpha, beta and Mac-1 on peripheral neutrophil obtained from healthy subjects.
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
May 1997,
Intensive care medicine,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
October 1998,
Clinical and experimental immunology,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
September 2001,
The European journal of surgery = Acta chirurgica,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
April 2002,
Obesity surgery,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
January 1996,
Skin pharmacology : the official journal of the Skin Pharmacology Society,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
January 1997,
Clinical hemorheology and microcirculation,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
January 1994,
Nephron,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
August 1994,
Transplantation proceedings,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
August 1981,
Journal of cell science,
S Kusano, and
H Mukae, and
T Morikawa, and
T Asai, and
H Sawa, and
N Morikawa, and
H Oda, and
O Sakito, and
C Shukuwa, and
R Senju
June 1993,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
