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Effects of scopolamine on performance of a delayed matching-to-sample task and on the properties of neurons in anterior-ventral inferior temporal (IT) cortex were examined in two monkeys. Both monkeys were impaired on the task after systemic administration of scopolamine, suggesting that scopolamine disrupts recency memory. Despite the behavioral deficit, neurons in IT cortex, a region having an important role in visual memory and neuronal properties consistent with that role, were largely unaffected by scopolamine. This dissociation between the behavioral and neuronal effects of scopolamine indicates that the drug either acts at a different site or disrupts unobserved mechanisms at the IT site.
E K Miller, and
R Desimone
January 1987,
Experimental brain research,
E K Miller, and
R Desimone
January 2010,
Experimental psychology,
E K Miller, and
R Desimone
January 2018,
Cellular and molecular neurobiology,
E K Miller, and
R Desimone
May 2008,
PLoS computational biology,
E K Miller, and
R Desimone
January 1997,
Behavioural neurology,
E K Miller, and
R Desimone
March 2005,
Physiology & behavior,
E K Miller, and
R Desimone
August 2007,
Physiology & behavior,
E K Miller, and
R Desimone
January 2021,
eNeuro,
E K Miller, and
R Desimone
April 1993,
Indian journal of experimental biology,
E K Miller, and
R Desimone
March 2023,
Psychological research,
