The effect of food on alcohol absorption and elimination patterns. 1993

R L Watkins, and E V Adler
Phoenix Crime Detection Laboratory, AZ.

The same nine subjects (six male, three female) were given near bolus doses of alcohol (0.69 g/kg) on two occasions separated by one week. They were instructed to consume the alcohol as rapidly as possible (12.1 min average). The alcohol was consumed after dilution to 15% with fruit punch mix. Both phases of the experiment were conducted in a similar manner with the exception of stomach condition. In Phase I the alcohol was consumed immediately after a large meal. In Phase II, the alcohol was consumed after an approximate 6 h fast. An Intoxilyzer 4011A was used to measure Breath Alcohol Concentration (BrAC), beginning immediately after the alcohol was consumed and ending approximately 4 h after the end of drinking. The BrACs were measured in grams per 210 L of breath, at approximate 8 min intervals over the course of the experiment. The alcohol absorption and elimination curves were plotted and evaluated for each subject in both experiments. The average time required to reach maximum BrAC was 41 min for both empty and full stomach conditions. The average elimination rate of ethanol was found to be significantly lower after meal (0.017 BrAC/h compared to 0.020 BrAC/h) but the time required to reach zero BrAC was not significantly different (5.01 h full stomach, 5.05 h empty stomach).

UI MeSH Term Description Entries
D008297 Male Males
D001944 Breath Tests Any tests done on exhaled air. Breathalyzer Tests,Breath Test,Breathalyzer Test,Test, Breath,Test, Breathalyzer,Tests, Breath,Tests, Breathalyzer
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000042 Absorption The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

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