Biomaterial Database

Influence of zinc-ligand mixtures on serum zinc levels in rats. 1977

E Giroux, and N J Prakash

The influence of various salts, chelates, and other complexes of zinc given by gavage on serum zinc levels in rats was studied. Serum zinc concentrations were determined over 6 hr after administration of zinc sulfate at doses of 5, 10, 20, 50, and 100 mg of zinc/kg. Serum zinc levels following doses of zinc salts and complexes were compared with those after zinc sulfate. Phytic acid, aminopolycarboxylic acids (including edetate disodium), and penicillamine significantly suppressed increases in serum zinc concentration. Some natural amino acid-zinc sulfate mixtures (those with lysine, cysteine, glycine, and histidine) produced greater levels than the equivalent dose of zinc sulfate alone. Several thiocarboxylic acids, such as mercaptoacetic acid and thiosalicylic acid, also increased serum zinc concentrations. These observations form a basis for attempted modification of zinc absorption in other species.

UI	MeSH Term	Description	Entries
D007408	Intestinal Absorption	Uptake of substances through the lining of the INTESTINES.	Absorption, Intestinal
D008024	Ligands	A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)	Ligand
D008297	Male		Males
D000440	Butanols	Isomeric forms and derivatives of butanol (C4H9OH).	Alcohols, Butyl,Butanol,Butylhydroxides,Hydroxybutanes,Butyl Alcohols
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D015032	Zinc	A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus