-transparent.png){kind=logo}
Acute lymphoblastic leukemia was diagnosed in an 11-year-old girl with mild signs of Down's syndrome. She was known since birth to have a constitutional mosaicism (46,XX/47,XX,+21c). At initial diagnosis of acute leukemia, additional chromosome changes were found in bone marrow blasts: hyperdiploidy > 50, with a structural abnormality. She was treated with a standard chemotherapeutic protocol, and has remained in complete remission for more than 3 years. The constitutional mosaicism evolved toward normalization year after year in the blood and under the effect of chemotherapy in the bone marrow.
Related Publications
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
March 2006,
Cancer genetics and cytogenetics,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
August 1987,
Cancer genetics and cytogenetics,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
January 2000,
Annales de dermatologie et de venereologie,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
April 1987,
Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
May 2020,
Journal of pediatric hematology/oncology,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
January 2016,
Cytogenetic and genome research,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
December 1974,
La Pediatria,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
January 1982,
American journal of human genetics,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
January 1996,
Cancer genetics and cytogenetics,
C Léonard, and
M R Avalos, and
F Miélot, and
M Poissonnier, and
J P Dommergues, and
J Lejeune, and
G Tchernia
January 2022,
Cytogenetic and genome research,
