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Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37. 1993
H H van Es, and
A Bout, and
J Liu, and
L Anderson, and
A M Duncan, and
P Bosma, and
R Oude Elferink, and
P L Jansen, and
J R Chowdhury, and
E Schurr
Department of Medicine, McGill University, Montréal, Québec, Canada.
UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.
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