The term Cyclophrenia substitute better for the term Manic-depressive Psychosis than the term Cyklothymia. Registered prevalence of Cyclophrenia in Bulgaria increase from 0,30% for 1960 to 0,74% for 1975, but there are some unregistered patients. The percentage of Cyclophrenia by resident patient rate in psychiatric hospitals increase from 5,54% for 1960 to 11,16% for 1975. Among 1741 cyclophrenic patients 55% have unipolar depression, 16% unipolar mania and 29% bipolar course. Mortality by Cyclophrenia is 1.5 more as in the general population. Cancer-diseases among our patients and their geneology occure more frequently than in control groups.