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The concentration of lysozyme in plasma (P) and in neutrophil leucocytes (N) was determined by a turbidimetric method in 32 patients with ulcerative colitis (U.C.), 11 patients with Crohn's disease (C.D.), 9 patients with haemorrhagic proctitis, and 39 healthy volunteers. In active U.C., P was significantly elevated (p less than 0.05), whereas C.D. showed normal values. Corresponding N was significantly reduced in active U.C. (p less than 0.05) but normal in C.D. In calculating the ratio N/P, highly significant lower values were found in active U.C. (p less than 0.001) compared to normal levels in C.D. The high P in active U.C. is presumed to reflect an accelerated destruction of neutrophil leucocytes as well as an intensified turnover rate. The reduced N is probably attributable to an inhibited synthesis. The findings suggest that lysozyme determinations are valuable in be differential diagnosis of active U.C. and C.D.
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
April 1980,
Hepato-gastroenterology,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
November 1985,
Scandinavian journal of gastroenterology,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
February 1975,
The New England journal of medicine,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
January 1976,
Scandinavian journal of gastroenterology,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
December 1977,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
June 1976,
Archives francaises des maladies de l'appareil digestif,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
June 1976,
Archives francaises des maladies de l'appareil digestif,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
April 1989,
Rinsho byori. The Japanese journal of clinical pathology,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
November 1977,
The American journal of digestive diseases,
O Koldkjaer, and
N A Klitgaard, and
K G Schmidt
April 1976,
Gut,
