BIOMAT Database Logo BIOMAT Database Logo

The RRE of human immunodeficiency virus type 1 contributes to cell-type-specific viral tropism. 1993

E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

As part of a general program investigating the mechanism of the Rev axis of human immunodeficiency virus type 1 (HIV-1) autoregulation, a series of proviral HIV-1 mutants which differ from the parental HXB2 strain at selected positions within the RRE were constructed. All of the mutations were designed to perturb the RRE by introducing local helix disruptions without altering the coding potential of the overlapping envelope open reading frame. Viral replication in various cell types was monitored by a cell supernatant reverse transcriptase assay and Northern (RNA blot) analysis. All proviral RRE mutants displayed at least some impairment in replication. However, the relative impairment varied drastically among the various cell types tested. This suggests that the RRE may contribute to cell-type-specific viral tropism.

UI MeSH Term Description Entries
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009690 Nucleic Acid Conformation The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape. DNA Conformation,RNA Conformation,Conformation, DNA,Conformation, Nucleic Acid,Conformation, RNA,Conformations, DNA,Conformations, Nucleic Acid,Conformations, RNA,DNA Conformations,Nucleic Acid Conformations,RNA Conformations
D011533 Proviruses Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. Proviruses are often associated with neoplastic cell transformation and are key features of retrovirus biology. Provirus
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D000163 Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993. AIDS,Immunodeficiency Syndrome, Acquired,Immunologic Deficiency Syndrome, Acquired,Acquired Immune Deficiency Syndrome,Acquired Immuno-Deficiency Syndrome,Acquired Immuno Deficiency Syndrome,Acquired Immuno-Deficiency Syndromes,Acquired Immunodeficiency Syndromes,Immuno-Deficiency Syndrome, Acquired,Immuno-Deficiency Syndromes, Acquired,Immunodeficiency Syndromes, Acquired,Syndrome, Acquired Immuno-Deficiency,Syndrome, Acquired Immunodeficiency,Syndromes, Acquired Immuno-Deficiency,Syndromes, Acquired Immunodeficiency
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA
D012367 RNA, Viral Ribonucleic acid that makes up the genetic material of viruses. Viral RNA
D014771 Virion The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos. Virus Particle,Viral Particle,Viral Particles,Particle, Viral,Particle, Virus,Particles, Viral,Particles, Virus,Virions,Virus Particles
D014779 Virus Replication The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle. Viral Replication,Replication, Viral,Replication, Virus,Replications, Viral,Replications, Virus,Viral Replications,Virus Replications

Related Publications

E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid.
June 2004, Journal of virology,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Influence of gag on human immunodeficiency virus type 1 species-specific tropism.
November 2004, Journal of virology,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Protein structural disorder of the envelope V3 loop contributes to the switch in human immunodeficiency virus type 1 cell tropism.
January 2017, PloS one,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Human immunodeficiency virus type 1 tropism for human macrophages.
January 1992, Pathobiology : journal of immunopathology, molecular and cellular biology,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Control of expression and cell tropism of human immunodeficiency virus type 1.
January 1990, Advances in virus research,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Viral Tropism in Human Immunodeficiency Virus Type 1-Infected Children and Adolescents in Thailand.
February 2021, Journal of the Pediatric Infectious Diseases Society,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages.
August 1996, Journal of virology,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism.
August 2002, Journal of virology,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation.
September 1990, Journal of virology,
E T Dayton, and D A Konings, and S Y Lim, and R K Hsu, and L Butini, and G Pantaleo, and A I Dayton
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
September 1991, Journal of virology,
Copied contents to your clipboard!