-transparent.png){kind=logo}
Urinary kallikrein excretion was measured before and after administration of spironolactone in 12 patients with essential hypertension (including 7 patients with low renin and 5 patients with normal renin) and 6 patients with primary aldosteronism. In low renin essential hypertension, two types of urinary kallikrein excretion were observed. In one type, urinary kallikrein decreased from 6.2+/-2.1 (S.E.) EU/day to 2.7+/-0.3 EU/day after the treatment. In another type, urinary kallikrein increased from 3.1+/-0.5 EU/day to 6.4+/-1.0 EU/day. In the former, plasma aldosteron showed high levels (12.3+/-2.1 ng/100 ml), while in the latter, it was normal (3.2+/-0.5 ng/100 ml). In normal renin essential hypertension, urinary kallikrein excretion did not alter after the treatment. In primary aldosteronism, urinary kallikrein showed moderate decrease after the spironolactone treatment from 8.5+/-1.6 EU/day to 4.2+/-1.6 EU/day. Spironolactone is said to compete directly with the effect of aldosterone at renal distal tubules. The present investigation suggests that urinary kalikrein excretion is related to the effective levels of aldosterone at renal distal tubules, and alteration of aldosterone levels mediates the release of kallikrein, and that there are different mechanisms in the renal handling of sodium and kallikrein in low renin essential hypertension, in normal renin essential hypertension, and in primary aldosteronism.
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
July 1978,
Clinical science and molecular medicine,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
June 1983,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
January 1989,
Advances in experimental medicine and biology,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
January 1979,
Minerva nefrologica,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
February 1980,
The Journal of clinical investigation,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
May 1981,
The Journal of clinical endocrinology and metabolism,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
September 1981,
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
October 2012,
Journal of clinical hypertension (Greenwich, Conn.),
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
October 1985,
Archives of disease in childhood,
M Seino, and
K Abe, and
Y Sakurai, and
N Irokawa, and
M Yasujima, and
S Chiba, and
Y Otsuka, and
K Yoshinaga
January 1981,
Kardiologia polska,
